Tuesday, 4 August 2015

Neuroprosthetics- A Bridge between Biotechnology & Medicine-I

In the context of the next generation medicine with the far fetched possibility of eliminating the most intriguing medicinal problems, Neuroprosthetics hold a special place in the near future. The way, in which bio-sensors have been in use in the last 25 years in developing methods to detect random fluctuations in the biomolecules of our system, it will be the era where most of the medical problems will be dealt via Neuroprosthetics.

Recently with the development of ARGUS II, a solution to eradicate blindness just explains how microelectronics and biology go hand in hand. The very concept of the image received being processed by a video processing unit and being transmitted to our brain is pretty much in line with the first application of Neuroprosthetics in cochlear implants. It known so that the array of micro-electrodes that are placed have specified functions, for example, 6-8 micro-electrodes are supposed to be the conveyor of the information, implies that the temporal information is passed through them and the speech is converted to noise. Least to say that cochlear implants are the most successful case of Neuroprosthetics in use over the last two decades. Even before the concept of ARGUS arose, it has always been the dream of neural researchers to work on vision problems. Initially they thought of direct stimulation of the visual area of the cerebral cortex but there were some mechanical problems discovered specially with the increased use of microelectrodes. Nevertheless, ARGUS after being in clinical trials for 3 years have finally been approved by FDA and soon will be commercially produced.

One of the most common techniques that orthopedics use is an amputation where the cases become severe with loss of tissue damage or else they go by placing titanium plates as a support for broken bones. In either way the patients have to undergo a lot of pain, and physiotherapy. A lot of physiotherapists use the transcutaneous nervous electrical stimulation (TENS) in order to treat pain. The micro-electrodes are placed on the skin over the various muscles and nerves. The electrically induced muscle contractions actually help to build muscle strength and other bulk range of motion. The principle is the same as that in normal pain treatment or in cases of muscle spasm in various regions by heat. The electrical stimulations excite the nerve ending and the transmission of impulse takes place via changes in membrane potential. The next step to this very method will be direct injection of single channel transmitters via hermetic packaging where they will be controlled by radio frequency generated by magnetic fields placed outside the patient’s body.

By careful visionary we can see that indeed with the advances in medical science and also the treatment procedures due to constant work in the field of microelectronics and bio-sensors, the problems of the external physical entity is being solved at a good pace. The only question still remains is about the molecular level diagnostics and its future. 


Debanjan Kundu

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